Peripheral blood antigen presenting cell responses in otitis-prone and non-otitis-prone infants
نویسندگان
چکیده
منابع مشابه
Sulphamethoxazole prophylaxis in the otitis-prone child.
A bedtime dose of sulphamethoxazole was effective in preventing ear infections in otitis-prone young children. Thirty-three such children were studied by means of a random, double-blind, placebo-controlled, cross-over protocol. Nine (27%) of 33 children treated with sulphamethoxazole experienced 10 episodes of acute suppurative otitis media or otitis media with effusion while 19 (58%) of 33 chi...
متن کاملDifferences in innate immune response gene regulation in the middle ear of children who are otitis prone and in those not otitis prone
OBJECTIVE Acute otitis media (AOM) causes an inflammatory response in the middle ear. We assessed differences in innate immune responses involved in bacterial defense at onset of AOM in children who were stringently defined as otitis prone (sOP) and children not otitis prone (NOP). STUDY DESIGN Innate immune genes analysis from middle ear fluid (MEF) samples of children. METHODS Genes of to...
متن کاملReduced serum IgG responses to pneumococcal antigens in otitis-prone children may be due to poor memory B-cell generation.
A low level of serum antibody to antigens expressed by Streptococcus pneumoniae has been proposed to explain the susceptibility of children to recurrent episodes of acute otitis media (hereafter, "otitis-prone children"). By use of enzyme-linked immunospot assays, the percentages of memory B cells to pneumococcal protein antigens PhtD, LytB, PcpA, PhtE, and Ply were compared between otitis-pron...
متن کاملNew Pneumococcal Carriage Acquired in Association with Acute Respiratory Infection Is Prone to Cause Otitis Media
For considering vaccine-prevention of pneumococcal acute otitis media (PncAOM), relationships between pneumococcal carriage, respiratory infection and PncAOM need to be understood. We analyzed nasopharyngeal samples collected from 329 unvaccinated Finnish children aged 2-24 months at scheduled visits and at visits during respiratory infection in 1994-97. We assessed temporal associations of res...
متن کاملOtitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides
The pneumococcus is a major otitis media (OM) pathogen, but data are conflicting regarding whether otitis-prone children have impaired humoral immunity to pneumococcal antigens. We and others have shown that otitis-prone and healthy children have similar antibody titers to pneumococcal proteins and polysaccharides (vaccine and nonvaccine types); however, the quality of antibodies from otitis-pr...
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ژورنال
عنوان ژورنال: Innate Immunity
سال: 2015
ISSN: 1753-4259,1753-4267
DOI: 10.1177/1753425915616267